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Chemometric analysis of bioimplants of bone tissues during their manufacture

Статья

The results of expanded spectral analysis of donor bone implants using the Raman spectroscopy method are presented in the work. Mathematical methods of improving resolution of spectral contours and chemometric analysis are used for evaluation of component composition of the implants. It is shown that the Raman spectroscopy can be used for evaluation of relative concentration of mineral and organic components in extracellular matrix of bone tissue. Spectral features of the samples of bone tissues demineralized and processed with ultrasound with different degree are found as a result of the study. The criteria allowing evaluating the component composition during manufacture of bioimplants are suggested in the work.

Averaged normalized Raman spectra of mineralized and demineralized samples of bioimplants, taken from cadaverous (1,4) and antemortem (2,3) bone tissue
where Ii – intensity of spectral lines of the analyzing components.
The graph of PCA counts of averaged Raman spectra of eight samples of bone tissue
The graph of PCA loads of spectral lines of the Raman spectra of the samples of bone tissues
Two-dimensional diagrams of the introduced coefficients: CB – Cadaveric without Ultrasound; CU – Cadaveric with Ultrasound; IB – Intravital without Ultrasound; IU – Intravital with Ultrasound
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